About SilicoScreen
At SilicoScreen (OPC) Pvt Ltd, the mission is to redefine safety assessment using cutting-edge in silico (computational) technology. A healthier world is fostered by transforming how the pharmaceutical, medical device, agrochemical, cosmetic, and food industries approach safety testing. By leveraging state-of-the-art computational methodologies and robust infrastructure, you can accelerate R&D, reduce costs, and minimise animal testing.
Our Expertise
SilicoScreen is a pioneer in providing in silico toxicology and biocompatibility testing services in India. All reports and services are generated in full compliance with ICH and OECD guidelines, ensuring global acceptance by major regulatory bodies like the US FDA, EMA, and UK MHRA.
Biocompatibility and Toxicity Prediction
The toxicological profiles of chemicals, APIs, and other substances are predicted.
Impurity Identification and Formation Analysis
API-Excipient and Drug-Drug Interaction Analysis
Prediction And Justification of Exposure Limits
Unknown impurities are identified & assessed, including through in silico forced degradation studies.
Regulatory Documentation Support
Our Unique Approach
Our approach combines a suite of in-house developed algorithms with industry-leading commercial software like Derek Nexus, Zeneth, and LeadScope. A key differentiator is the specialised analogue selection algorithm, which helps achieve high-accuracy predictions by using multiple analogues for each assessment. Access to over 70 toxicity databases is maintained, and collaborations are held with a panel of DABT (Diplomate of the American Board of Toxicology) fellows for expert reviews and regulatory submissions.
This unique workflow has a proven impact, with documented results showing a reduction in testing time by up to 98%, costs by 80%, and animal use by 75% compared to traditional methods. A flexible pay-per-use model is operated, making services accessible to organisations of all sizes.
To learn more about how SilicoScreen can support your specific needs, please submit your inquiries via the contact page.
Advantages At SilicoScreen
Proprietary Technology
A key differentiator is SilicoScreen’s proprietary algorithm for analogue selection and data-gap filling, which enables high-accuracy predictions. This technology underpins the company’s expert-based and statistical (QSAR) models, integrating structural alerts, chemical properties, and experimental datasets. By using multiple analogues for each assessment, SilicoScreen enhances the reliability and regulatory acceptance of its predictions.